She is much more knowledgable than me when it comes to the facts of vaccinization. So, I have asked her to share some of that knowledge with us.
Immunisation – Things to Consider
By Mel Morns, MPH
The Delicate Immune System
The natural adaptive immune response
provides the human immune system with the ability to recognize and
remember specific pathogens (to generate immunity), and to mount
stronger attacks each time the pathogen is encountered. It is
adaptive immunity because the body's immune system prepares itself
for future challenges and development of immunological memory, in
which each pathogen is remembered by a signature antibody. These
memory cells can be called upon to quickly eliminate a pathogen
should subsequent infections occur. (Wiki)
We know that the postnatal maturation of immune competence is not complete after birth but takes some time to develop. http://onlinelibrary.wiley.com/doi/10.1111/j.1399-3038.1995.tb00261.x/abstract Giving very young children multiple immunisations at once can confuse their still developing immune system and trigger immune dysfunction in the form of autoimmune disease. The immune system is very complex and in some people easily confused… this is what happens when a person has an auto-immune response. http://www.jimmunol.org/cgi/content/meeting_abstract/188/1_MeetingAbstracts/58.23
Adaptive immunity relies on the capacity of immune cells to
distinguish between the body's own cells and unwanted invaders. The
host's cells express "self" antigens. These antigens are
different from those on the surface of bacteria or on the surface of
virally infected host cells. The adaptive response is triggered by
recognizing non-self and missing-self antigens. This is what is
happening when the immune system attacks part of the body that it
should not… and this causes an illness. Some common auto-immune
illnesses are;
- Irritable Bowel Syndrome
- Celiac Disease
- Asthma
- Multiple Sclerosis
- Diabetes type 1
- Allergies
Interestingly we do not see much auto
immune illness in developing countries where immunisation levels are
much lower. This has also been labelled the hygiene hypothesise.
http://www.coronadobiosciences.com/products/hygiene-hypothesis.cfm
The concern for vaccines compromising immune regulation is not just about many disease agents given at once, but also additives in vaccines, most of which have not been tested for cumulative effects in children. When we consider that children under the age of 6 months are not recommended to have anything but breast milk or formula by mouth, then it seems only logical to be concerned about injecting the vaccine excipients straight into the blood stream.
The following excipients are used in vaccines given to babies under the age of one:
Albumin, Bovine - used in IPV (Polio)
and DTaP (Diphtheria, tetanus, and pertussis)
2-Phenoxyethanol - a bactericide used in DTaP (Diphtheria, tetanus, and pertussis)
Aluminium - DTaP, HepB, IPV (Hepatitis B, Polio, Diphtheria, tetanus, and pertussis)
Formaldehyde - DTaP, HepB, IPV (Hepatitis B, Polio, Diphtheria, tetanus, and pertussis)
Gelatin - DTaP (Diphtheria, tetanus, and pertussis)
Yeast - DTaP, HepB, IPV (Hepatitis B, Polio, Diphtheria, tetanus, and pertussis)
http://www.vaccinesafety.edu/components-Excipients.htm
National Immunisation Program up to the age of 1 in Australia and the US
Birth
Hepatitis B (hepB)a
8 weeks (2 months)
Hepatitis B (hepB)
Diphtheria, tetanus and whooping cough (acellular pertussis) (DTPa)
Haemophilus influenzae type b (Hib)
Polio (inactivated poliomyelitis IPV)
Pneumococcal conjugate (13vPCV)
Rotavirus
16 weeks (4 months)
Hepatitis B (hepB)
Diphtheria, tetanus and whooping cough (acellular pertussis (DTPa)
Haemophilus influenzae type b (Hib)
Polio (inactivated poliomyelitis IPV)
Pneumococcal conjugate (13vPCV)
Rotavirus
6 months
Hepatitis B (hepB)
Diphtheria, tetanus and whooping cough (acellular pertussis (DTPa)
Haemophilus influenzae type b (Hib)
Polio (inactivated poliomyelitis) (IPV)
Pneumococcal conjugate (13vPCV)
Rotavirus b
12 months
Haemophilus influenzae type b (Hib)
Measles, mumps and rubella (MMR)
Meningococcal C (MenCCV)
http://www.cdc.gov/vaccines/parents/downloads/rec-iz-babies.pdf
Prevalence Rates
Something else to consider is prevalence rates, from a twofold perspective. First we must ask the question which immunisations actually work? When we consider ‘herd’ immunity will protect the population when most are immunised, then why are some diseases being wiped out (like Polio and Tetanus) by vaccine treatment while others seem to have a natural cycle that is not being affected at all (Pertussis). http://www.health.gov.au/internet/main/publishing.nsf/content/cda-cdi3102g.htm Are all vaccines equally effective or do some work better than others?
ACIR data indicated, at 31 December 2008, 92% of one year olds, 93% of two year olds (see graph 11.23 in the link below) and 89% of six year olds were fully immunised according to the NHMRC Recommended Australian Standard Vaccination Schedule. http://www.abs.gov.au/ausstats/abs@.nsf/39433889d406eeb9ca2570610019e9a5/E4277318BCD03B96CA25773700169C89
For the prevalence of immunisation in the US:
http://www.cdc.gov/nchs/fastats/immunize.htm
Secondly, if a condition has been wiped out in your country, then what is the rush to vaccinate a very small baby whose immune system is still developing? Perhaps those vaccines that clearly work, and have reduced the incidence of that condition so well, can be delayed until the child has a more developed immune system.
Here are some links that can give you more information on how prevalent the diseases we immunise against actually are.
Notifiable disease prevalence Australia http://apps.who.int/immunization_monitoring/en/globalsummary/timeseries/TSincidenceByCountry.cfm?C=AUS
Notifiable disease prevalence USA http://apps.who.int/immunization_monitoring/en/globalsummary/timeseries/TSincidenceByCountry.cfm?C=USA
Global Polio Prevalence
Global Pertussis Prevelence
Some Australian Government data on
adverse effects after immunisation
DTPa, dTpa, hepatitis B, Hib, IPV and their various combinations may cause transient minor adverse events including swelling, redness or soreness at the injection site, and low-grade fever, crying and irritability (in infants). There is an increased risk of more extensive local adverse events after booster doses of DTPa and DTPa-combination vaccines. A local adverse event that involves extensive limb swelling should be reported.
http://www.health.gov.au/internet/immunise/publishing.nsf/Content/Handbook-adverse
http://www.health.gov.au/internet/main/publishing.nsf/Content/cda-2004-cdi2804h.htm
More serious adverse events following immunisation Taken from the Australian Government Department of Health and Aging Immunisation Handbook
http://www.health.gov.au/internet/immunise/publishing.nsf/Content/Handbook-appendix6
Abscess
Occurrence of a fluctuant or draining fluid-filled lesion at the site of injection, with or without fever.
Bacterial: purulent collection.
Sterile abscess: no evidence of bacterial infection.
Acute flaccid paralysis [diagnosis must be made by a physician]
Acute onset of flaccid paralysis of one or more limbs following any vaccine.
Allergic reaction (generalised)
A non-anaphylactic,
generalised reaction characterised by 1 or more symptoms or signs of
skin and/or gastrointestinal tract involvement WITHOUT respiratory or
cardiovascular involvement.
Anaphylaxis: A rapidly evolving generalised multi-system allergic reaction characterised by 1 or more symptoms or signs of respiratory and/or cardiovascular involvement AND involvement of other systems such as the skin or gastrointestinal tract.
Respiratory: difficulty/noisy breathing, swelling of the tongue, swelling/tightness in the throat, difficulty talking/hoarse voice, wheeze or persistent cough.
Cardiac: loss of consciousness, collapse, pale and floppy (babies), hypotension.
Arthralgia: Joint pain without redness or swelling.
Arthritis: Joint pain with redness and/or swelling.
Brachial neuritis: Pain in arm causing persisting weakness of limb on side of vaccination.
Death: Any death of a vaccine recipient temporally linked to vaccination, where no other clear cause of death can be established.
Disseminated BCG: Disseminated infection occurring after BCG vaccination and confirmed by isolation of Mycobacterium bovis BCG strain.
Encephalopathy [diagnosis must be made by a physician]: Encephalopathy is an acute onset of major neurological illness temporally linked with vaccination and characterised by any 2 or more of the following 3 conditions:
seizures,
severe alteration in level of consciousness or mental status (behaviour and/or personality)lasting for 1 day or more, and/or
focal neurological signs which persist for 1 day or more.
Encephalitis [diagnosis must be made by a physician]: Encephalitis is characterised by the above-mentioned symptoms and signs of cerebral inflammation and, in many cases, CSF pleocytosis and/or virus isolation.
Extensive limb swelling
Swelling of the limb, with or without redness, which:
extends from the joint above to the joint below the injection site, or beyond a joint (above or below the injection site), or
results in the circumference of the limb being twice the normal size.
Faint
See ‘Vasovagal episode’.
Fever: Only very high fever should be reported, eg. >40.5oC.
Guillain-Barré Syndrome (GBS) [diagnosis must be made by a physician]
Acute onset of rapidly progressive, ascending, symmetrical flaccid paralysis, without fever at onset of paralysis and with or without sensory loss. Cases are diagnosed by cerebrospinal fluid (CSF) investigation showing dissociation between cellular count and protein content.
Hypotonic–hyporesponsive episode (shock, collapse):The sudden onset of pallor or cyanosis, limpness (muscle hypotonia), and reduced responsiveness or unresponsiveness occurring after vaccination, where no other cause is evident such as a vasovagal episode or anaphylaxis. The episode usually occurs 1 to 48 hours after vaccination and resolves spontaneously.
Injection site reaction (severe)
Reaction (redness and/or swelling) at site of injection which:
persists for more than 3 days AND is associated with ongoing symptoms such as pain or an inability to use the limb (see ‘Brachial neuritis’ above), and
does not fulfil the case definition for extensive limb swelling (see ‘Extensive limb swelling’ above), or
requires hospitalisation.
Intussusception [diagnosis must be made by a hospital physician]
The invagination of a proximal segment of bowel into the distal bowel lumen.
Lymphadenitis (includes suppurative lymphadenitis)
Occurrence of either:
at least 1 lymph node, 1.5 cm in diameter or larger, or
a draining sinus over a lymph node.
Meningitis [diagnosis must be made by a physician]: Acute onset of major illness with fever and often neck stiffness/positive meningeal signs (Kernig, Brudzinski) and with CSF pleocytosis.
Nodule
A discrete or well demarcated soft tissue mass or lump that is firm and is at the injection site in the absence of abscess formation, warmth and erythema.
Orchitis: Swelling with pain and/or tenderness of testes.
Osteitis: Inflammation of the bone due to BCG vaccination.
Osteomyelitis: Proven bacterial infection of bone.
Parotitis: Swelling and/or tenderness of parotid gland or glands.
Rash: Severe or unusual rash.
Screaming (persistent): The presence of crying which is continuous and unaltered for longer than 3 hours.
Seizure
Witnessed sudden loss of consciousness and generalised, tonic, clonic, tonic-clonic, or atonic motor manifestations.
febrile seizures: with fever ≥38.5oC,
afebrile seizures: without fever,
syncopal seizures: syncope/vasovagal episode followed by seizure(s).
Sepsis: Acute onset of severe, generalised illness due to bacterial infection and confirmed by positive blood culture.
Subacute sclerosing panencephalitis [diagnosis must be made by a physician]
Degenerative central nervous system (CNS) condition with laboratory confirmation of abnormal serum and CSF measles antibodies.
Syncope
See ‘Vasovagal episode’.
Thrombocytopenia: Platelet count <50 x 109/L.
Toxic shock syndrome [diagnosis must be made by a physician]: Abrupt onset of fever, vomiting, watery diarrhoea and shock within a few hours of vaccination as can be associated with other conditions listed here.
Vaccine-associated paralytic poliomyelitis
See ‘Acute flaccid paralysis’.
Vasovagal episode (syncope, faint) : Episode of pallor and unresponsiveness or reduced responsiveness or feeling light headed AND
occurring while vaccine being administered or shortly after (usually within 5 minutes), AND
bradycardia, AND
resolution of symptoms with change in position (supine position or head between knees or limbs elevated).
(See Table 1.5.1 to distinguish from anaphylaxis).
Other severe or unusual events
Any unusual event that does not fit into any of the categories listed above, but is of medical or epidemiological interest, should be reported with a detailed description of the clinical features.
Mel, thank you so much for sharing knowledge and research with us!
If you want to do more research on the topic I would highly recommend that you check these books out:
The Vaccine Book by Robert Sears, MD
What Your Doctor May Not Tell You About Children's Vaccinations by Stephanie Cave, MD
Vaccines: Are they Really Safe and Effective? by Neil Z. Miller
Here are a few great websites for vaccine info:
http://www.nvic.org/
http://www.vaccinesafety.edu/
If you are interested in either not vaccinating or vaccinating on an alternative schedule you will probably want to find a doctor who will work with these wishes. AskDrSears.com has a great list of doctors who are "vaccine friendly".
Make sure you know your rights when it comes to choosing whether or not to vaccinate your child. Check here to find out about the laws in your state:
http://www.nvic.org/vaccine-laws/state-vaccine-requirements.aspx
Good luck to all of you making this decision for your children. It can be a very difficult choice, but if you make sure you are fully informed, you can feel confident with whatever you decide.














